uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Effect of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women
Show others and affiliations
2011 (English)In: Journal of Lipid Research, ISSN 0022-2275, E-ISSN 1539-7262, Vol. 52, no 10, 1821-1828 p.Article in journal (Refereed) Published
Abstract [en]

Consumption of industrially produced trans fatty acids (IP-TFA) has been positively associated with systemic markers of low-grade inflammation and endothelial dysfunction in cross-sectional studies, but results from intervention studies are inconclusive. Therefore, we conducted a 16 week double-blind parallel intervention study with the objective to examine the effect of IP-TFA intake on bio-markers of inflammation, oxidative stress, and endothelial dysfunction. Fifty-two healthy overweight postmenopausal women (49 completers) were randomly assigned to receive either partially hydrogenated soybean oil (15.7 g/day IP-TFA) or control oil without IP-TFA. After 16 weeks, IP-TFA intake increased baseline-adjusted serum tumor necrosis factor (TNF) alpha by 12% [95% confidence interval (CI): 5-20; P = 0.002] more in the IP-TFA group compared with controls. Plasma soluble TNF receptors 1 and 2 were also increased by IP-TFA [155 pg/ml (CI: 63-247); P < 0.001 and 480 pg/ml (CI: 72-887); P = 0.02, respectively]. Serum C-reactive protein, interleukin (IL) 6 and adiponectin and subcutaneous abdominal adipose tissue mRNA expression of IL6, IL8, TNF alpha, and adiponectin as well as ceramide content were not affected by IP-TFA, nor was urinary 8-iso-prostaglandin-F(2 alpha). In conclusion, this dietary trial indicates that the mechanisms linking dietary IP-TFA to cardiovascular disease may involve activation of the TNF alpha system.

Place, publisher, year, edition, pages
2011. Vol. 52, no 10, 1821-1828 p.
Keyword [en]
fatty acids, dietary intervention, oxidative stress, ceramide, subcutaneous adipose tissue
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-159218DOI: 10.1194/jlr.M014738ISI: 000294727500005OAI: oai:DiVA.org:uu-159218DiVA: diva2:444139
Available from: 2011-09-28 Created: 2011-09-26 Last updated: 2011-09-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Oxidative Stress and Inflammation
In the same journal
Journal of Lipid Research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 106 hits
ReferencesLink to record
Permanent link

Direct link