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Discovery of lost diversity of paternal horse lineages using ancient DNA
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
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2011 (English)In: Nature Communications, ISSN 2041-1723, Vol. 2, 450- p.Article in journal (Refereed) Published
Abstract [en]

Modern domestic horses display abundant genetic diversity within female-inherited mitochondrial DNA, but practically no sequence diversity on the male-inherited Y chromosome. Several hypotheses have been proposed to explain this discrepancy, but can only be tested through knowledge of the diversity in both the ancestral (pre-domestication) maternal and paternal lineages. As wild horses are practically extinct, ancient DNA studies offer the only means to assess this ancestral diversity. Here we show considerable ancestral diversity in ancient male horses by sequencing 4 kb of Y chromosomal DNA from eight ancient wild horses and one 2,800-year-old domesticated horse. Both ancient and modern domestic horses form a separate branch from the ancient wild horses, with the Przewalski horse at its base. Our methodology establishes the feasibility of re-sequencing long ancient nuclear DNA fragments and demonstrates the power of ancient Y chromosome DNA sequence data to provide insights into the evolutionary history of populations.

Place, publisher, year, edition, pages
2011. Vol. 2, 450- p.
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-159488DOI: 10.1038/ncomms1447ISI: 000294806500043OAI: oai:DiVA.org:uu-159488DiVA: diva2:445195
Available from: 2011-10-03 Created: 2011-10-03 Last updated: 2011-10-03Bibliographically approved

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