Lung function, respiratory symptoms, and the menopausal transition
2008 (English)In: Journal of Allergy and Clinical Immunology, ISSN 0091-6749, Vol. 121, no 1, 72-80.e3 p.Article in journal (Refereed) Published
BACKGROUND: There is limited information on potential changes in respiratory health when women enter the menopausal transition. OBJECTIVE: We sought to investigate whether the menopausal transition is related to lung function and asthma and whether body mass index (BMI) modifies associations. METHODS: Four thousand two hundred fifty-nine women from 21 centers (ECRHS II, 2002) responded to a questionnaire concerning women's health. Women aged 45 to 56 years not using exogenous sex hormones (n = 1274) were included in the present analysis. Lung function measurements (n = 1120) and serum markers of hormonal status (follicle-stimulating hormone, luteinizing hormone, and estradiol; n = 710) were available. Logistic and linear regression analyses were adjusted for BMI, age, years of education, smoking status, center, and height. RESULTS: Women not menstruating for the last 6 months (n = 432, 34%) had significantly lower FEV(1) values (-120 mL [95% CI, -177 to -63]), lower forced vital capacity values (-115 mL [95% CI, -181 to -50]), and more respiratory symptoms (odds ratio [OR], 1.82 [95% CI, 1.27-2.61]) than those menstruating regularly. Results were similar when restricting analyses to those who never smoked. Associations were significantly stronger in women with BMIs of less than 23 kg/m(2) (respiratory symptoms: OR, 4.07 [95% CI, 1.88-8.80]; FEV(1) adjusted difference: -166 [95% CI, -263 to -70]) than in women with BMIs of 23 to 28 kg/m(2) (respiratory symptoms: OR, 1.10 [95% CI, 0.61-1.97], P(interaction): .04; FEV(1) adjusted difference, -54 [95% CI, -151 to 43], P(interaction) = .06). CONCLUSIONS: Menopause is associated with lower lung function and more respiratory symptoms, especially among lean women.
Place, publisher, year, edition, pages
2008. Vol. 121, no 1, 72-80.e3 p.
Asthma/epidemiology, Body Mass Index, Female, Forced Expiratory Volume, Humans, Hypersensitivity/epidemiology/etiology, Menopause, Middle Aged, Respiration Disorders/epidemiology/etiology, Respiratory Function Tests, Respiratory Physiology, Vital Capacity, Women's Health
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-16795DOI: 10.1016/j.jaci.2007.08.057ISI: 000252372000011PubMedID: 18028993OAI: oai:DiVA.org:uu-16795DiVA: diva2:44566