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Impaired endothelial function and elevated levels of pentraxin 3 in early-onset preeclampsia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2012 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 91, no 1, 50-56 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To study endothelial function in relation to anti-angiogenic biomarkers and the inflammatory process in preeclampsia.

Design: Observational study.

Setting: Data were obtained from pregnant women who were admitted to the obstetrical ward at the Karolinska University Hospital, Solna, Stockholm, Sweden. Population. Thirty-five women with newly developed and untreated preeclampsia and 30 healthy controls.

Methods: Flow-mediated dilation of the brachial artery, levels of anti-angiogenic and inflammatory markers were measured in plasma during pregnancy and 3-6 months after delivery. Main outcome measures. Flow-mediated dilation of the brachial artery, anti-angiogenic and inflammatory markers.

Results: Flow-mediated dilation was decreased in the preeclamptic group at inclusion and at follow-up (p<0.05). Pentraxin 3 (PTX3) and ratio of soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) were elevated in women with preeclampsia during pregnancy (p<0.001). Furthermore flow-mediated dilation was lower and the ratio sFlt-1/PlGF and PTX3 were higher in early-onset preeclampsia than late preeclampsia (p=0.018, 0.002 and 0.039). Levels of PTX3 at inclusion correlated inversely with flow-mediated dilation at follow-up both in the preeclampsia and control groups (Spearman, r(s) =-0.47, p=0.02 and r(s) =-0.46, p=0.02 respectively).

Conclusion: Impaired endothelial function and increased ratio sFlt/PlGF, elevated PTX3 is present in women with preeclampsia and is especially pronounced in women with early-onset preeclampsia.

Place, publisher, year, edition, pages
2012. Vol. 91, no 1, 50-56 p.
Keyword [en]
Anti-angiogenesis markers, endothelium, inflammatory, Pentraxin 3, preeclampsia
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-159605DOI: 10.1111/j.1600-0412.2011.01238.xISI: 000297922200010PubMedID: 21751969OAI: oai:DiVA.org:uu-159605DiVA: diva2:445716
Available from: 2011-10-04 Created: 2011-10-04 Last updated: 2012-02-08Bibliographically approved

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