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Optimising islet engraftment is critical for successful clinical islet transplantation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Clinical Immunology.
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2008 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 51, no 2, 227-32 p.Article in journal (Refereed) Published
Abstract [en]

Clinical islet transplantation is currently being explored as a treatment for persons with type 1 diabetes and hypoglycaemia unawareness. Although 'proof-of-principle' has been established in recent clinical studies, the procedure suffers from low efficacy. At the time of transplantation, the isolated islets are allowed to embolise the liver after injection in the portal vein, a procedure that is unique in the area of transplantation. A novel view on the engraftment of intraportally transplanted islets is presented that could explain the low efficacy of the procedure.

Place, publisher, year, edition, pages
2008. Vol. 51, no 2, 227-32 p.
Keyword [en]
Clinical, Engraftment, Innate immunity, Intraportal, Intramuscular, Islet transplantation, Liver morphology, Thrombosis, Tumour metastasis, Revascularisation
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-16835DOI: 10.1007/s00125-007-0868-9ISI: 000251995200004PubMedID: 18040664OAI: oai:DiVA.org:uu-16835DiVA: diva2:44606
Available from: 2008-06-05 Created: 2008-06-05 Last updated: 2017-12-08Bibliographically approved

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Korsgren, OlleTufveson, GunnarNilsson, Bo

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