Unexpected effects of donor gender on the storage of liquid plasma
2007 (English)In: Vox Sanguinis, ISSN 0042-9007, E-ISSN 1423-0410, Vol. 93, no 3, 223-228 p.Article in journal (Refereed) Published
BACKGROUND: Swedish regulations in effect since 2006 allow the storage of plasma for transfusion up to 14 days at 2-6 degrees C and for 3 years at < or = -30 degrees C. In this study, the quality of currently used plasma components was investigated. MATERIALS AND METHODS: Plasma components, prepared from whole blood or by apheresis, either leucocyte depleted or not leucocyte depleted, were stored at 2-6 degrees C as liquid plasma or as thawed fresh-frozen plasma; 31% were from female donors. Concentration, function and activation markers of the plasma coagulation systems were investigated during storage for up to 42 days. RESULTS: Cold-induced contact activation was the dominant storage lesion, occurring earlier and at higher frequency in plasma from females. Increased kallikrein-like activity led to changes in activated partial thromboplastin time, prothrombin time, protein C and C1 inhibitor (C1INH). C1INH function dropped to 53% on Day 14 in cold-activated plasma components. CONCLUSION: Contact activation may be triggered before Day 14, especially in plasma from females, and may progress as a result of the consumption of C1INH. The data suggest that lack of cold-induced contact activation may be an important quality criterion. To achieve this, plasma from male donors could be selected for transfusion and the storage time limited to 7 days.
Place, publisher, year, edition, pages
2007. Vol. 93, no 3, 223-228 p.
C1 inhibitor, Contact activation, Donor gender, Long-term storage, Plasma preparation
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-16836DOI: 10.1111/j.1423-0410.2007.00963.xISI: 000249436600007PubMedID: 17845259OAI: oai:DiVA.org:uu-16836DiVA: diva2:44607