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Predictors of postnatal outcome in neonates with gastroschisis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Paediatric Surgery.
2011 (English)In: Journal of Pediatric Surgery, ISSN 0022-3468, E-ISSN 1531-5037, Vol. 46, no 11, 2108-2114 p.Article in journal (Refereed) Published
Abstract [en]

Background/Purpose: The optimal management of neonates with gastroschisis is unclear and there is a significant morbidity. We performed a review of neonates with gastroschisis treated at our center of pediatric surgery over the last 21-years in order to determine predictive factors of outcome.

Methods: Single-center retrospective analysis of 79 neonates with gastroschisis (1989 to 2009). Ā Length of hospital stay (LOS), days of parenteral nutrition (PN) and survival were outcome measures. Univariate and multiple regression analyses were used.

Results: Overall survival was 92 % and primary closure was achieved in 80 %. Median LOS was 25 days and median duration on PN 17 days. Intestinal atresia, closed gastroschisis, secondary closure and sepsis were the primary variables associated with poor outcome independent of other variables, but prematurity also had an effect on outcome. Route of delivery and associated malformations were not related to poorer outcome. Necrotizing enterocolitis (NEC) did not occur in any of our patients.

Conclusion: Outcome in our patients was favorable as measured by survival, LOS, and days on PN. Primary predictors of poor outcome were factors related to short bowel syndrome (SBS) and secondary closure, indicating a need to further improve treatment of SBS.

Place, publisher, year, edition, pages
2011. Vol. 46, no 11, 2108-2114 p.
Keyword [en]
Gastroschisis, Postnatal outcome, Predictive factors, Short bowel syndrome
National Category
Surgery
Identifiers
URN: urn:nbn:se:uu:diva-159709DOI: 10.1016/j.jpedsurg.2011.07.012ISI: 000296869100017OAI: oai:DiVA.org:uu-159709DiVA: diva2:446407
Available from: 2011-10-07 Created: 2011-10-07 Last updated: 2017-12-08Bibliographically approved

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Engstrand Lilja, Helene

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