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Influence of iron and zinc status on cadmium accumulation in Bangladeshi women
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Internationell kvinno- & mödrahälsovård/Essén)
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2007 (English)In: Toxicology and Applied Pharmacology, ISSN 0041-008X, E-ISSN 1096-0333, Vol. 222, no 2, 221-226 p.Article in journal (Refereed) Published
Abstract [en]

Cadmium is a widespread environmental contaminant present in food. The absorption in the intestine increases in individuals with low iron stores, but the effect of zinc deficiency is not clear. The aim of the present study was to assess the influence of iron and zinc status on cadmium accumulation in pregnant Bangladeshi women. We measured cadmium in urine from 890 women using inductively coupled plasma mass spectrometry (ICPMS). Further, we also measured ferritin and zinc in plasma. The median cadmium concentration in urine was 0.59 μg/L (adjusted to mean specific gravity of 1.012 g/mL). Analysis of covariance (ANCOVA) showed that urinary cadmium was associated with plasma ferritin and plasma zinc via a significant interaction between dichotomized plasma ferritin and plasma zinc. The analysis was adjusted for age and socioeconomic status. Women with low iron stores and adequate zinc status had significantly higher urinary cadmium compared to women with both adequate iron stores and zinc status. There was no difference in urinary cadmium between women with both low iron stores and zinc status compared to those with both adequate iron stores and zinc status. In conclusion, low iron stores were associated with increased cadmium accumulation, but only at adequate zinc status.

Place, publisher, year, edition, pages
2007. Vol. 222, no 2, 221-226 p.
Keyword [en]
Bangladesh, Cadmium, Cadmium accumulation, Plasma ferritin, Plasma zinc
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-16881DOI: 10.1016/j.taap.2007.04.009ISI: 000248401000010PubMedID: 17543360OAI: oai:DiVA.org:uu-16881DiVA: diva2:44652
Available from: 2008-06-09 Created: 2008-06-09 Last updated: 2011-01-24Bibliographically approved

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Ekström, Eva-CharlottePersson, Lars-Åke
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