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Innate immunity activation on biomaterial surfaces: a mechanistic model and coping strategie
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. (Bo Nilsson)
University of Pennsylvania.
Götebors universitet.
University of Pennsylvania.
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2011 (English)In: Advanced Drug Delivery Reviews, ISSN 0169-409X, E-ISSN 1872-8294, Vol. 63, no 12, 1042-1050 p.Article, review/survey (Refereed) Published
Abstract [en]

When an artificial biomaterial (e.g., a stent or implantable pump) is exposed to blood, plasma proteins immediately adhere to the surface, creating a new interface between the biomaterial and the blood. The recognition proteins within the complement and contact activation/coagulation cascade systems of the blood will be bound to, or inserted into, this protein film and generate different mediators that will activate polymorphonuclear leukocytes and monocytes, as well as platelets. Under clinical conditions, the ultimate outcome of these processes may be thrombotic and inflammatory reactions, and consequently the composition and conformation of the proteins in the initial layer formed on the surface will to a large extent determine the outcome of a treatment involving the biomaterial, affecting both the functionality of the material and the patient's life quality. This review presents models of biomaterial-induced activation processes and describes various strategies to attenuate potential adverse reactions by conjugating bioactive molecules to surfaces or by introducing nanostructures.

Place, publisher, year, edition, pages
2011. Vol. 63, no 12, 1042-1050 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-159757DOI: 10.1016/j.addr.2011.06.012ISI: 000295861600009PubMedID: 21771620OAI: oai:DiVA.org:uu-159757DiVA: diva2:446801
Available from: 2011-10-10 Created: 2011-10-10 Last updated: 2011-11-11Bibliographically approved

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Nilsson Ekdahl, KristinaTeramura, YujiNicholls, IanNilsson, Bo
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Department of Immunology, Genetics and PathologyDepartment of Biochemistry and Organic Chemistry
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