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Low diurnal variability of apolipoprotein A1, apolipoprotein B and apolipoprotein B/apolipoprotein A1 ratio during normal sleep and after an acute shift of sleep
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Biokemisk struktur och funktion)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Biokemisk struktur och funktion)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Biokemisk struktur och funktion)
2008 (English)In: Clinical Biochemistry, ISSN 0009-9120, E-ISSN 1873-2933, Vol. 41, no 10-11, 859-862 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: The aim of this study was to study the diurnal variation of the cardiovascular risk markers apolipoprotein A1 and B and apo B/apo A1 ratio. DESIGN AND METHODS: We have studied the diurnal variation of apolipoprotein A1, apolipoprotein B and apo B/apo A1 ratio during night sleep and the day sleep conditions in seven healthy volunteers (age 22-32 yr). Samples were collected every hour to evaluate the effect of different sampling times on the test results. RESULTS: The lowest diurnal coefficient of variation (CV) was observed for the apo B/apo A1 ratio, which usually was below 2% but also apolipoprotein A1, apolipoprotein B showed low CV. There were no significant differences between nightsleep and daysleep for any of the studied markers. CONCLUSION: Even if there was a diurnal variation for these markers, the variation was very low. Thus, sampling does not have to be restricted to certain times of the day.

Place, publisher, year, edition, pages
2008. Vol. 41, no 10-11, 859-862 p.
Keyword [en]
Apolipoprotein A1, Apolipoprotein B, Diurnal variation, Human
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-16912DOI: 10.1016/j.clinbiochem.2008.02.018ISI: 000257101900015PubMedID: 18387362OAI: oai:DiVA.org:uu-16912DiVA: diva2:44683
Available from: 2008-06-10 Created: 2008-06-10 Last updated: 2017-12-08Bibliographically approved

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Larsson, AndersCarlsson, Lena

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