uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease: an overview
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Inflammation)
2007 (English)In: Expert Review of Molecular Diagnostics, ISSN 1473-7159, E-ISSN 1744-8352, Vol. 7, no 4, 435-451 p.Article in journal (Refereed) Published
Abstract [en]

HIV-1 protease has a broad and complex substrate specificity, which hitherto has escaped a simple comprehensive definition. This, and the relatively high mutation rate of the retroviral protease, makes it challenging to design effective protease inhibitors. Several attempts have been made during the last two decades to elucidate the enigmatic cleavage specificity of HIV-1 protease and to predict cleavage of novel substrates using bioinformatic analysis methods. This review describes the methods that have been utilized to date to address this important problem and the results achieved. The data sets used are also reviewed and important aspects of these are highlighted.

Place, publisher, year, edition, pages
2007. Vol. 7, no 4, 435-451 p.
Keyword [en]
Computational Biology/*methods/*trends, HIV-1/*enzymology, Humans, Models; Chemical, Peptide Hydrolases/*chemistry/*metabolism, Substrate Specificity/physiology
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-16940DOI: 10.1586/14737159.7.4.435PubMedID: 17620050OAI: oai:DiVA.org:uu-16940DiVA: diva2:44711

Publikation från annat universitet

Available from: 2008-06-10 Created: 2008-06-10 Last updated: 2015-06-18

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17620050&dopt=Citation

Search in DiVA

By author/editor
Garwicz, Daniel
By organisation
Department of Medical Sciences
In the same journal
Expert Review of Molecular Diagnostics
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 396 hits
ReferencesLink to record
Permanent link

Direct link