Highly packed and aligned fluoride substituted hydroxyapatite via a surfactant-free process
2012 (English)In: Journal of Biomedical Materials Research. Part B - Applied biomaterials, ISSN 1552-4973, E-ISSN 1552-4981, Vol. 100B, no 1, 75-81 p.Article in journal (Refereed) Published
Biomolecules and surfactants are believed to be the key factors for reconstruction of tooth enamel and preparation of fluoride hydroxyapatite coating with enamel-like structure on dental implants. We have developed an alternative surfactant-free biomimetic method to stimulate growth of fluoride substituted hydroxyapatite coatings with highly packed and aligned structure on metallic substrates. Oxidized titanium plates were chosen as the substrates. The biomimetic fluoride hydroxyapatite was prepared by immersing the pretreated Ti plates into the phosphate-buffered solution with Ca2+, H2PO4-, HPO42-, and F-. The pH value was controlled at 7.4 at the beginning. Every titanium plate (10 mm x 10 mm x 1 mm) was soaked into 20 mL of ion doped phosphate buffered solution in sealed plastic bottles, kept at 37 degrees C or 60 degrees C without stirring for time periods of 1 day to 2 weeks. After immersion, the samples were removed from the solution, rinsed with deionized water and allowed to dry in air. The fluoride substituted hydroxyapatite layer, composed of needle-like crystallites with the diameter of 1020 nm, was well-organized and tightly packed. XRD results showed a sharper and stronger (002) peak, which could be used to explain that there was a preferable orientation along the c axis. The coating could be reconstructed on the former layer if the mineralization process was repeated, and the structure of the coating could be preserved. The method could be used to construct well organized fluoride substitute hydroxyapatite coating on metal implants.
Place, publisher, year, edition, pages
2012. Vol. 100B, no 1, 75-81 p.
fluoride substituted hydroxyapatite, biomimetic, enamel, implant coating
Biomaterials Science Engineering and Technology
Research subject Engineering Science with specialization in Materials Science
IdentifiersURN: urn:nbn:se:uu:diva-159879DOI: 10.1002/jbm.b.31924ISI: 000297949800009OAI: oai:DiVA.org:uu-159879DiVA: diva2:447281