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U-2973, a novel B-cell line established from a patient with a mature B-cell leukemia displaying concurrent t(14;18) and MYC translocation to a non-IG gene partner
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine. (Hematologi)
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2008 (English)In: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 81, no 3, 218-225 p.Article in journal (Refereed) Published
Abstract [en]

B-cell lymphomas/leukemias with simultaneous t(14;18)(q32;q21) and MYC rearrangements have recently been shown to constitute a separate diagnostic entity, presenting with a rapid clinical course and a very poor prognosis. We describe the establishment of an Epstein-Barr virus negative cell line, designated U-2973, from a male patient with a de novo aggressive B-cell lymphoma/leukemia and very high peripheral blast cell count. Flow cytometry of bone marrow cells and U-2973 displayed a mature B-cell phenotype, and immunostaining showed expression of MYC and BCL2. IG gene rearrangement data were consistent with a lymphoid neoplasm of germinal centre derivation. Cytogenetic studies using conventional G-banding, fluorescent in situ hybridization, spectral karyotyping and single nucleotide polymorphism array demonstrated a complex karyotype with both a t(14;18) and double translocations between MYC and a non-IG gene partner located at chromosome 12p12.1.

Place, publisher, year, edition, pages
2008. Vol. 81, no 3, 218-225 p.
Keyword [en]
t(14;18), IGH/BCL2, MYC, B-cell, lymphoma, leukemia, cell line
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-16962DOI: 10.1111/j.1600-0609.2008.01098.xISI: 000258325600007PubMedID: 18510704OAI: oai:DiVA.org:uu-16962DiVA: diva2:44733
Available from: 2008-06-11 Created: 2008-06-11 Last updated: 2017-12-08Bibliographically approved

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Boström, HansLeuchowius, Karl-JohanThörn, IngridRosenquist, RichardSöderberg, OlaSundström, Christer

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European Journal of Haematology
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