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Differential expression of the five somatostatin receptor subtypes in human benign and malignant insulinomas: predominance of receptor subtype 4
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry. (Clinical Chemistry)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
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2007 (English)In: Endocrine pathology, ISSN 1046-3976, E-ISSN 1559-0097, Vol. 18, no 2, 79-85 p.Article in journal (Refereed) Published
Abstract [en]

Insulinomas constitute a subgroup of pancreatic endocrine tumors showing B cell differentiation and clinical symptoms related to inappropriate insulin secretion (WHO). Many endocrine tumors express somatostatin receptors (sstrs), which can be visualized by octreotide scintigraphy; however, about half of all insulinomas are reported to be negative. Previous immunohistochemical investigations with antibodies to sstr subtypes 1, 2, 3, and 5 have revealed differences in expression between various neuroendocrine tumors. In the present study, the immunoreactivity to all five human sstr was studied in ten benign and six malignant human insulinomas. Sstr4 was the receptor subtype most frequently expressed in both benign and malignant tumors. A difference in the immunohistochemical sstr5 expression pattern was seen between benign and malignant tumors: Three of the six malignant tumors, but none of the benign tumors, expressed sstr5. The other receptor subtypes were expressed in low numbers with no difference between benign and malignant tumors. The finding of a strong expression of sstr4 in both benign and malignant insulinomas suggests that this receptor subtype could be of importance for diagnostic and therapeutic use.

Place, publisher, year, edition, pages
2007. Vol. 18, no 2, 79-85 p.
Keyword [en]
Animals, Blotting; Western, COS Cells, Cercopithecus aethiops, Electrophoresis; Polyacrylamide Gel, Humans, Immunohistochemistry, Insulinoma/*genetics/*metabolism/pathology, Membrane Proteins/biosynthesis/genetics, Neoplasm Metastasis/genetics/pathology, Pancreatic Neoplasms/*genetics/*metabolism/pathology, Receptors; Somatostatin/*biosynthesis/*genetics, Tissue Fixation, Transfection
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-17005DOI: 10.1007/s12022-007-0014-8ISI: 000250098000004PubMedID: 17916997OAI: oai:DiVA.org:uu-17005DiVA: diva2:44776
Available from: 2008-06-24 Created: 2008-06-24 Last updated: 2017-12-08Bibliographically approved

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Stridsberg, MatsGrimelius, Lars

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