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The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnover.
Swedish University of Agricultural Sciences, Department of Molecular Biosciences.
Swedish University of Agricultural Sciences, Department of Molecular Biosciences.
Swedish University of Agricultural Sciences, Department of Molecular Biosciences,.
2003 (English)In: Journal of Experimental Medicine, ISSN 0022-1007, E-ISSN 1540-9538, Vol. 198, no 3, 423-31 p.Article in journal (Refereed) Published
Abstract [en]

To gain insight into the biological role of mast cell chymase we have generated a mouse strain with a targeted deletion in the gene for mast cell protease 4 (mMCP-4), the mouse chymase that has the closest relationship to the human chymase in terms of tissue localization and functional properties. The inactivation of mMCP-4 did not affect the storage of other mast cell proteases and did not affect the number of mast cells or the mast cell morphology. However, mMCP-4 inactivation resulted in complete loss of chymotryptic activity in the peritoneum and in ear tissue, indicating that mMCP-4 is the main source of stored chymotrypsin-like protease activity at these sites. The mMCP-4 null cells showed markedly impaired ability to perform inactivating cleavages of thrombin, indicating a role for mMCP-4 in regulating the extravascular coagulation system. Further, a role for mMCP-4 in connective tissue remodeling was suggested by the inability of mMCP-4 null peritoneal cells to process endogenous fibronectin.

Place, publisher, year, edition, pages
2003. Vol. 198, no 3, 423-31 p.
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Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-160055DOI: 10.1084/jem.20030671PubMedID: 12900518OAI: oai:DiVA.org:uu-160055DiVA: diva2:447886
Available from: 2011-10-13 Created: 2011-10-13 Last updated: 2017-12-08

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Tchougounova, Elena

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