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Affibody molecules: new protein domains for molecular imaging and targeted tumor therapy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Biomedical Radiation Sciences. (BMS)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Biomedical Radiation Sciences. (BMS)
2007 (English)In: Current opinion in drug discovery & development, ISSN 1367-6733, E-ISSN 2040-3437, Vol. 10, no 2, 167-175 p.Article, review/survey (Refereed) Published
Abstract [en]

Molecular imaging shows promise as a useful tool to aid drug discovery and development and also to provide important prognostic and predictive diagnostic information affecting patient management in the clinic. However, the use of molecular imaging diagnostically is not widely adopted, in part due to the lack of suitable targeting agents. Affibody molecules are a class of small and very stable protein domains, which can be used to selectively address a wide range of protein targets. Their small size enables high contrast radionuclide imaging and they can be produced by conventional peptide synthesis methods. Their potential utility in molecular imaging is highlighted in a large number of animal studies using anti-HER2 Affibody tracers and has recently been validated in breast cancer patients with HER2-expressing metastases. The therapeutic efficacy of the Affibody molecules in this indication was demonstrated in preclinical models using a targeted radionuclide as the effector function. This review will focus on the recent use of Affibody molecules for molecular imaging and their application for radioimmunotherapy.

Place, publisher, year, edition, pages
2007. Vol. 10, no 2, 167-175 p.
Keyword [en]
Animals, Antibodies/*diagnostic use, Diagnostic Imaging, Humans, Immunoglobulin G/immunology, Molecular Probes/*diagnostic use/*therapeutic use, Neoplasms/*diagnosis/*therapy, Radiopharmaceuticals/diagnostic use
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-17043ISI: 000244858400007PubMedID: 17436552OAI: oai:DiVA.org:uu-17043DiVA: diva2:44814
Available from: 2008-06-16 Created: 2008-06-16 Last updated: 2017-12-08Bibliographically approved

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Tolmachev, Vladimir

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