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Patients with palmoplantar pustulosis have increased IL-17 and IL-22 levels both in the lesion and serum
Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Dermatology and Venereology.
Division of Dermatology, University of California, San Diego, CA, USA.
Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
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2011 (English)In: Experimental dermatology, ISSN 0906-6705, E-ISSN 1600-0625, Vol. 20, no 10, 845-847 p.Article in journal (Refereed) Published
Abstract [en]

Recent findings about the pathogenesis of pustulosis palmaris et plantaris (PPP), also known as palmoplantar pustulosis, suggest that IL-17 expression in the acrosyringium as well as infiltration of IL-17 positive cells, e. g. Langerhans cells may play important roles. However, to date, it has not been established whether circulating IL-17 related cytokines are involved in PPP. We studied the circulating IL-17 related cytokines as well as the mRNA levels in lesional skin. IL-17 related cytokine mRNAs were increased in the PPP lesions compared with the control tissues (five patients vs five controls). The serum levels of TNF-alpha, IL-17, IL-22 and IFN-gamma also were significantly increased in PPP, but not IL-23 and IL-8 (48 patients vs 20 controls). Our findings document that not only the serum IL-17 but also tissue IL-17 are elevated in PPP and may be in the pathogenesis of this disorder.

Place, publisher, year, edition, pages
2011. Vol. 20, no 10, 845-847 p.
Keyword [en]
IL-17, IL-22, lesion tissue, palmoplantar pustulosis, serum
National Category
Medical and Health Sciences
Research subject
Dermatology and Venerology
URN: urn:nbn:se:uu:diva-160129DOI: 10.1111/j.1600-0625.2011.01325.xISI: 000295012600037OAI: oai:DiVA.org:uu-160129DiVA: diva2:448565
Available from: 2011-10-17 Created: 2011-10-17 Last updated: 2016-02-17

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