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Quantification of intramyocellular lipids in obese subjects using spectroscopic imaging with high spatial resolution
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biomedical Informatics and Engineering. (Ahlström)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology. (Ahlström)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2007 (English)In: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 57, no 1, 22-28 p.Article in journal (Refereed) Published
Abstract [en]

Quantification of intramyocellular lipids (IMCL) in obese subjects by single-voxel spectroscopy (SVS) or conventional spectroscopic imaging (SI) often fails due to overlap of IMCL spectral lines by extramyocellular lipids (EMCL), and signal contamination from subcutaneous fat and bone marrow. This study demonstrates that these problems can be solved by high-resolution SI with 128 phase-encoding steps and a read gradient during acquisition. The small voxels obtained in this way facilitated differentiation between EMCL and IMCL. This method offers the possibility of studying different muscle groups and the variation of lipids within one muscle.

Place, publisher, year, edition, pages
2007. Vol. 57, no 1, 22-28 p.
Keyword [en]
Adult, Body Mass Index, Female, Humans, Image Enhancement, Leg, Lipids/*analysis, Magnetic Resonance Spectroscopy/*methods, Middle Aged, Muscle Fibers/*chemistry/metabolism, Muscle; Skeletal/*chemistry/metabolism, Obesity, Reference Values
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-17088DOI: 10.1002/mrm.21085ISI: 000243538900004PubMedID: 17152088OAI: oai:DiVA.org:uu-17088DiVA: diva2:44859
Available from: 2008-06-16 Created: 2008-06-16 Last updated: 2017-12-08Bibliographically approved

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Weis, JanJohansson, LarsCourivaud, FredericAhlström, Håkan

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