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Plasma tau protein in comatose patients after cardiac arrest treated with therapeutic hypothermia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
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2011 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 55, no 9, 1132-1138 p.Article in journal (Refereed) Published
Abstract [en]

Background: Neurological outcome after cardiac arrest (CA) is difficult to predict in the acute phase. In this pilot study, we assessed blood levels of tau protein as a prognostic marker for the neurological outcome after 6 months in patients treated with hypothermia after resuscitation from CA. Methods: 22 unconscious patients resuscitated after CA were treated with mild hypothermia (32-34 degrees C) for 26 h. Blood samples were collected at 2, 6, 12, 24, 48, and 96 h after CA, and the concentration of tau protein was analyzed. Neurological outcome was assessed with the Glasgow-Pittsburgh cerebral performance category (CPC) scale at intensive care unit (ICU) discharge and after 6 months. The higher of the two CPC scores was used. Results: At ICU discharge, 21/22 patients were alive, of whom 10 had a good (CPC 1-2) outcome. After 6 months, 15/22 patients were alive, of whom 14 had a good outcome. Tau protein levels were higher among those with a poor outcome at 48 h and 96 h. At 96 h sampling, tau concentration predicted a poor outcome (CPC 3-5) with a sensitivity of 71% and a specificity of 93%. Conclusions: Although in a pilot study, a late increase in plasma tau protein seems to be associated with a worse outcome after hypothermia treatment after CA, although more studies are needed.

Place, publisher, year, edition, pages
2011. Vol. 55, no 9, 1132-1138 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-160125DOI: 10.1111/j.1399-6576.2011.02505.xISI: 000295102500014OAI: oai:DiVA.org:uu-160125DiVA: diva2:448622
Available from: 2011-10-17 Created: 2011-10-17 Last updated: 2017-12-08Bibliographically approved

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Mörtberg, ErikNordmark, J.Rubertsson, Sten

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