Parental occupational exposure to pesticides and the risk of childhood leukemia in Costa Rica
2007 (English)In: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, Vol. 33, no 4, 293-303 p.Article in journal (Refereed) Published
OBJECTIVES: Parental exposure to pesticides and the risk of leukemia in offspring were examined in a population-based case-control study in Costa Rica. METHODS: All cases of childhood leukemia (N=334), in 1995-2000, were identified at the Cancer Registry and the Children's Hospital. Population controls (N=579) were drawn from the National Birth Registry. Interviews of parents were conducted using conventional and icon-based calendar forms. An exposure model was constructed for 25 pesticides in five time periods. RESULTS: Mothers' exposures to any pesticides during the year before conception and during the first and second trimesters were associated with the risk [odds ratio (OR) 2.4, 95% confidence interval (95% CI) 1.0-5.9; OR 22, 95% CI 2.8-171.5; OR 4.5, 95% CI 1.4-14.7, respectively] and during anytime (OR 2.2, 95% CI 1.0-4.8). An association was found for fathers' exposures to any pesticides during the second trimester (OR 1.5, 95% CI 1.0-2.3). An increased risk with respect to organophosphates was found for mothers during the first trimester (OR 3.5, 95% CI 1.0-12.2) and for fathers during the year before conception and the first trimester (OR 1.5, 95% CI 1.0-2.2 and OR 1.6, 95% CI 1.0-2.6, respectively), and benzimidazoles during the first, second, and third trimesters of pregnancy (OR 2.2, 95% CI 1.0-4.4; OR 2.2, 95% CI 1.0-5.0; OR 2.2, 95% CI 1.0-5.2, respectively). There was a suggestion of an exposure-response gradient for fathers as regards picloram, benomyl, and paraquat. Age at diagnosis was positively associated with fathers' exposures and inversely associated with mothers' exposures. CONCLUSIONS: The results suggest that parental exposure to certain pesticides may increase the risk of leukemia in offspring.
Place, publisher, year, edition, pages
2007. Vol. 33, no 4, 293-303 p.
Adolescent, Child, Child; Preschool, Costa Rica/epidemiology, Female, Humans, Infant, Infant; Newborn, Interviews as Topic, Leukemia/epidemiology/*etiology, Male, Occupational Exposure, Odds Ratio, Parents, Pesticides/*adverse effects, Registries, Risk Assessment
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-17101PubMedID: 17717622OAI: oai:DiVA.org:uu-17101DiVA: diva2:44872