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Regulation of cellular steroid levels with special focus on oxysterol and estrogen metabolism
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2008 (English)In: Future Lipidology, ISSN 1746-0875, Vol. 3, no 3, 337-346 p.Article, review/survey (Refereed) Published
Abstract [en]

Steroids play essential roles in a number of physiological systems. However, disturbed functions or abnormal levels of steroids can result in serious health problems. The cellular levels of steroids are regulated by enzymes and other factors that control the formation and elimination of these compounds. Recent findings on steroid action and metabolism have identified novel links between two groups of steroids, oxysterols and estrogens. A better understanding of cellular processes related to these steroids is of interest for developing future therapies in several conditions, including endocrine tumors and hyperlipidemia.

Place, publisher, year, edition, pages
2008. Vol. 3, no 3, 337-346 p.
Keyword [en]
atherosclerosis, cholesterol homeostasis, estrogen, hormone-dependent cancer, hyperlipidemia, metabolism, oxysterol, SERM, sex hormone, steroid
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-17124DOI: 10.2217/17460875.3.3.337ISI: 000256284700016OAI: oai:DiVA.org:uu-17124DiVA: diva2:44895
Available from: 2008-06-17 Created: 2008-06-17 Last updated: 2011-01-13Bibliographically approved

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Norlin, Maria
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