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Vasodilation in resistance arteries is related to the apolipoprotein B/A1 ratio in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
2007 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 190, no 2, 378-384 p.Article in journal (Refereed) Published
Abstract [en]

Background: Recent studies have shown the apolipoprotein B to apolipoprotein A1 ratio (apoB/A1) to be superior to LDL-cholesterol measurements to predict cardiovascular events. The present study aims to relate apoB/A1 to endothelium-dependent vasodilation, an early marker of atherosclerosis, in the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study. Methods and results: In this population-based study, 1016 subjects aged 70 years were evaluated by the invasive forearm technique with acetylcholine (EDV), brachial artery ultrasound to assess flow-mediated vasodilation (FMD) and pulse wave analysis with a beta-2 receptor agonist challenge, terbutaline. EDV and the pulse wave response, but not FMD, were related to apoB/A1 levels (r = -0.11, p = 0.0038 for EDV, r = -0.16, p < 0.0001 for the pulse wave analysis and r = 0.01, p = 0.65 for FMD). Neither LDL-cholesterol, nor non-HDL-cholesterol, was significantly related to the measurements of endothelium-dependent vasodilation. Also endothelium-independent vasodilation (EIDV) evaluated by the invasive forearm technique with sodium nitroprusside was related to apoB/A1 levels (r = -0.12, p < 0.0016). Conclusion: The apoB/A1 levels, but not LDL-cholesterol, were inversely related to endothelium-dependent vasodilation evaluated by EDV and pulse wave analysis, but not by FMD. Also EIDV showed the same pattern, suggesting a general deterioration in vasoreactivity mainly in resistance arteries in elderly subjects with high apoB/A1 levels.

Place, publisher, year, edition, pages
2007. Vol. 190, no 2, 378-384 p.
Keyword [en]
Apolipoprotein, Endothelium, Lipids, Vasodilation
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-17125DOI: 10.1016/j.atherosclerosis.2006.02.027ISI: 000244173000018PubMedID: 16545386OAI: oai:DiVA.org:uu-17125DiVA: diva2:44896
Available from: 2008-06-17 Created: 2008-06-17 Last updated: 2011-02-14Bibliographically approved

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