uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
The new oral immunomodulating drug DiNAC induces brachial artery vasodilatation at rest and during hyperemia in hypercholesterolemic subjects, likely by a nitric oxide-dependent mechanism
Show others and affiliations
2008 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 196, no 1, 275-282 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: To investigate if the immunomodulator drug DINAC (1) affects arterial dimensions in asymptomatic patients with hypercholesterolemia, (2) has effects on leucocyte markers of inflammation and (3) has in vitro effects on nitric oxide synthase (NOS) in human umbilical vein endothelial cells (HIUVEC).

Methods and results: One hundred and fifty-three patients with asymptomatic hypercholesterolemia were randomized to either 100 or 500 mg of DINAC or placebo in a double-blind, parallel-group fashion for 24 weeks. Treatment at the highest dose induced a significant increase in resting brachial artery diameter measured by ultrasound and also induced a significant increase in vessel diameter during hyperemia. However, flow-mediated vasodilation (FMD) and the vasodilatory response to nitroglycerin, lipid levels or leukocyte count were unaltered. Expression of several cell surface markers of inflammation, like CD11b and CD25, were reduced by treatment. In vitro, DINAC counteracted TNF-alpha induced reductions in NO levels and in NOS protein and mRNA levels.

Conclusion: The immunomodulator drug DINAC increased brachial artery diameter at rest and during hyperemia in asymptomatic subjects with hypercholesterolemia without affecting blood lipid levels. Based on parallel in vitro studies this effect is likely due to an enhancement of NOS activity.

Place, publisher, year, edition, pages
2008. Vol. 196, no 1, 275-282 p.
Keyword [en]
endothelium, vasodilation, ultrasound, immune system, nitric oxide
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-17135DOI: 10.1016/j.atherosclerosis.2006.10.031ISI: 000253341500035PubMedID: 17157857OAI: oai:DiVA.org:uu-17135DiVA: diva2:44906
Available from: 2008-06-17 Created: 2008-06-17 Last updated: 2011-04-26Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Medical Sciences
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 119 hits
ReferencesLink to record
Permanent link

Direct link