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Mental stress impairs endothelial vasodilatory function by a beta-adrenergic mechanism
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
2007 (English)In: Endothelium, ISSN 1062-3329, E-ISSN 1029-2373, Vol. 14, no 3, 151-156 p.Article in journal (Refereed) Published
Abstract [en]

Mental stress has been shown to impair endothelium-dependent vasodilation (EDV) in the human forearm. The aim of this study was to investigate if this response could be blunted by local infusions of beta-blockade (propranolol), alpha-blockade (phentolamine), or neurogenic blockade. Thirty-one young healthy volunteers underwent forearm blood flow (FBF) measurements, using venous occlusion plethysmography, during local intra-arterial infusions of metacholine (MCh; inducing EDV) and sodium nitroprussid (SNP; inducing endothelial-independent vasodilation [EIDV]), respectively. These measurements were repeated during a 5-min mental arithmetic stress test without (n = 8) or with concomitant local infusion of propranolol (n = 7) or phentolamine (n = 8) in the forearm or during axillary plexus blockade (n = 8). An index of endothelial vasodilatory function (EFI) was calculated as the EDV to EIDV ratio. Mental stress impaired EDV significantly (p < .05), and as a result, EFI was significantly reduced (p = .02). This effect on EFI could be blocked by propranolol and neurogenic blockade but not by phentolamine (p < .05). Thus, impairment of endothelial vasodilatory function induced by mental stress could be blocked by beta-adrenergic, but not alpha-adrenergic, receptor blockade.

Place, publisher, year, edition, pages
2007. Vol. 14, no 3, 151-156 p.
Keyword [en]
Beta-Blockade, Blood Flow, Endothelium, Stress, Vasodilation
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-17238DOI: 10.1080/10623320701421420ISI: 000247729400004PubMedID: 17578709OAI: oai:DiVA.org:uu-17238DiVA: diva2:45009
Available from: 2008-06-18 Created: 2008-06-18 Last updated: 2017-12-08Bibliographically approved

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