Mental stress impairs endothelial vasodilatory function by a beta-adrenergic mechanism
2007 (English)In: Endothelium, ISSN 1062-3329, E-ISSN 1029-2373, Vol. 14, no 3, 151-156 p.Article in journal (Refereed) Published
Mental stress has been shown to impair endothelium-dependent vasodilation (EDV) in the human forearm. The aim of this study was to investigate if this response could be blunted by local infusions of beta-blockade (propranolol), alpha-blockade (phentolamine), or neurogenic blockade. Thirty-one young healthy volunteers underwent forearm blood flow (FBF) measurements, using venous occlusion plethysmography, during local intra-arterial infusions of metacholine (MCh; inducing EDV) and sodium nitroprussid (SNP; inducing endothelial-independent vasodilation [EIDV]), respectively. These measurements were repeated during a 5-min mental arithmetic stress test without (n = 8) or with concomitant local infusion of propranolol (n = 7) or phentolamine (n = 8) in the forearm or during axillary plexus blockade (n = 8). An index of endothelial vasodilatory function (EFI) was calculated as the EDV to EIDV ratio. Mental stress impaired EDV significantly (p < .05), and as a result, EFI was significantly reduced (p = .02). This effect on EFI could be blocked by propranolol and neurogenic blockade but not by phentolamine (p < .05). Thus, impairment of endothelial vasodilatory function induced by mental stress could be blocked by beta-adrenergic, but not alpha-adrenergic, receptor blockade.
Place, publisher, year, edition, pages
2007. Vol. 14, no 3, 151-156 p.
Beta-Blockade, Blood Flow, Endothelium, Stress, Vasodilation
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-17238DOI: 10.1080/10623320701421420ISI: 000247729400004PubMedID: 17578709OAI: oai:DiVA.org:uu-17238DiVA: diva2:45009