Evaluation of spinal and bulbar muscular atrophy by the clustering index method
2011 (English)In: Muscle and Nerve, ISSN 0148-639X, E-ISSN 1097-4598, Vol. 44, no 4, 539-546 p.Article in journal (Refereed) Published
Introduction: A reliable electrophysiological marker for clinical trials is increasingly needed in spinal and bulbar muscular atrophy (SBMA). We previously developed a quantitative analysis method for surface electromyography (SEMG), the clustering index (CI) method. Our purpose was to test the utility of the CI method for evaluating lower motor neuron involvement in SBMA patients.
Methods: Subjects included 29 SBMA patients and 27 healthy controls. The recording electrode was placed over the abductor digiti minimi (ADM) muscle with a proximal reference. The Z-score, based on the CI method, was compared with compound muscle action potential (CMAP) amplitude and motor unit number estimation (MUNE), with regard to sensitivity.
Results: The Z-scores of the CI method, CMAP amplitude, and MUNE were abnormal in 100%, 72%, and 93% of the patients, respectively. Interrater reliability of the CI method was sufficiently high.
Conclusion: The CI method is promising as a non-invasive electrophysiological marker in SBMA.
Place, publisher, year, edition, pages
2011. Vol. 44, no 4, 539-546 p.
compound muscle action potential, motor unit number estimation, quantitative analysis, spinal and bulbar muscular atrophy, surface EMG
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-160384DOI: 10.1002/mus.22119ISI: 000295402000011OAI: oai:DiVA.org:uu-160384DiVA: diva2:450998