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Ankle brachial index <0.9 underestimates the prevalence of peripheral artery occlusive disease assessed with whole-body magnetic resonance angiography in the elderly
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2008 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 49, no 2, 143-149 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Whole-body magnetic resonance angiography (WBMRA) permits noninvasive vascular assessment, which can be utilized in epidemiological studies. PURPOSE: To assess the relation between a low ankle brachial index (ABI) and high-grade stenoses in the pelvic and leg arteries in the elderly. MATERIAL AND METHODS: WBMRA was performed in a population sample of 306 subjects aged 70 years. The arteries below the aortic bifurcation were graded after the most severe stenosis according to one of three grades: 0-49% stenosis, 50-99% stenosis, or occlusion. ABI was calculated for each side. RESULTS: There were assessable WBMRA and ABI examinations in 268 (right side), 265 (left side), and 258 cases (both sides). At least one > or =50% stenosis was found in 19% (right side), 23% (left side), and 28% (on at least one side) of the cases. The corresponding prevalences for ABI <0.9 were 4.5%, 4.2%, and 6.6%. An ABI cut-off value of 0.9 resulted in a sensitivity, specificity, and positive and negative predictive value of 20%, 99%, 83%, and 84% on the right side, and 15%, 99%, 82%, and 80% on the left side, respectively, for the presence of a > or =50% stenosis in the pelvic or leg arteries. CONCLUSION: An ABI <0.9 underestimates the prevalence of peripheral arterial occlusive disease in the general elderly population.

Place, publisher, year, edition, pages
2008. Vol. 49, no 2, 143-149 p.
Keyword [en]
Aged, Ankle/*blood supply, Arterial Occlusive Diseases/*diagnosis/epidemiology, Brachial Artery/*physiopathology, Cohort Studies, Contrast Media/administration & dosage, Female, Gadolinium DTPA/diagnostic use, Humans, Image Enhancement/methods, Imaging; Three-Dimensional/methods, Leg/blood supply, Magnetic Resonance Angiography/*methods, Male, Pelvis/blood supply, Peripheral Vascular Diseases/*diagnosis/epidemiology, Predictive Value of Tests, Prevalence, Prospective Studies, Sensitivity and Specificity, Severity of Illness Index, Whole Body Imaging/*methods
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-17337DOI: 10.1080/02841850701732957ISI: 000253642300005PubMedID: 18300136OAI: oai:DiVA.org:uu-17337DiVA: diva2:45108
Available from: 2008-06-19 Created: 2008-06-19 Last updated: 2017-12-08Bibliographically approved

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Wikström, JohanHansen, TomasJohansson, LarsAhlström, Håkan

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