PopED: An extended, parallelized, nonlinear mixed effects models optimal design tool
2012 (English)In: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 108, no 2, 789-805 p.Article in journal (Refereed) Published
Several developments have facilitated the practical application and increased the general use of optimal design for nonlinear mixed effects models. These developments include new methodology for utilizing advanced pharmacometric models, faster optimization algorithms and user friendly software tools. In this paper we present the extension of theoptimal design software PopED, which incorporates many of these recent advances into aneasily useable enhanced GUI. Furthermore, we present new solutions to problems related to the design of experiments such as: faster and more robust FIM calculations and optimizations, optimizing over cost/utility functions and diagnostic tools and plots to evaluate designperformance. Examples for; (i) Group size optimization and efficiency translation, (ii) Cost/constraint optimization, (iii) Optimizations with different FIM approximations and (iv) optimization with parallel computing demonstrate the new features in PopED and underline the potential use of this tool when designing experiments.
Place, publisher, year, edition, pages
2012. Vol. 108, no 2, 789-805 p.
IdentifiersURN: urn:nbn:se:uu:diva-160475DOI: 10.1016/j.cmpb.2012.05.005ISI: 000310828200030OAI: oai:DiVA.org:uu-160475DiVA: diva2:451146