Venous thromboembolism in association with features of the metabolic syndrome
2007 (English)In: QJM Monthly Journal of the Association of Physicians, ISSN 1460-2725, E-ISSN 1460-2393, Vol. 100, no 11, 679-684 p.Article in journal (Refereed) Published
Background: Central obesity, diabetes mellitus, dyslipidaemia and chronic hypertension-features of the metabolic syndrome-have been individually associated with venous thromboembolism (VTE). However, whether each of these factors additively increases the risk of VTE is uncertain. Aim: To determine whether features of the metabolic syndrome independently increase the risk of VTE. Design: Prospective cohort study derived from the Heart Outcomes Prevention Evaluation 2 (HOPE-2) randomized clinical trial. Setting: One hundred and forty-five clinical centres in 13 countries. Methods: We studied 5522 adults aged >55 years with cardiovascular disease or diabetes mellitus. At enrolment, 35% had 0-1 features of the metabolic syndrome, 30% had two, 24% had three and 11% had four. We defined symptomatic VTE as an objectively confirmed new episode of deep-vein thrombosis or pulmonary embolism. Results: VTE occurred in 88 individuals during a median 5.0 years of follow-up. The incidence rate of VTE (per 100 person-years) was 0.30 with 0-1 features, 0.36 with two features, 0.38 with three features and 0.40 with four features of the metabolic syndrome (trend p=0.43). Relative to the presence of 0-1 features of the metabolic syndrome, the adjusted hazard ratio (95%Cl) for VTE was 1.22 (0.71-2.08) with two features, 1.25 (0.70-2.24) with three features, and 1.26 (0.59-2.69) with four features. Discussion: The number of features of the metabolic syndrome present was not a clinically important risk factor for VTE in older adults with vascular arterial disease.
Place, publisher, year, edition, pages
2007. Vol. 100, no 11, 679-684 p.
Adult, Aged, Blood Glucose/analysis, Blood Pressure, Body Mass Index, Cohort Studies, Female, Humans, Incidence, Male, Metabolic Syndrome X/blood/*complications/epidemiology, Middle Aged, Obesity/epidemiology, Odds Ratio, Risk Factors, Triglycerides/blood, Venous Thromboembolism/*epidemiology, Waist-Hip Ratio
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-17367DOI: 10.1093/qjmed/hcm083PubMedID: 17846056OAI: oai:DiVA.org:uu-17367DiVA: diva2:45138