Systemic exposure of the parent drug oxaliplatin during hyperthermic intraperitoneal perfusion
2008 (English)In: European Journal of Clinical Pharmacology, ISSN 0031-6970, European Journal of Clinical Pharmacology, Vol. 64, no 9, 907-911 p.Article in journal (Refereed) Published
Objective To evaluate the perfusate and systemic kinetics of oxaliplatin during hyperthermic intraperitoneal chemotherapy (HIPEC) using a selective analytical technique. Methods HIPEC was carried out in eight patients by the open abdomen coliseum technique for 30 min at 41.5-43 degrees C with an average of 427 mg/m(2) of oxaliplatin in 5% dextrose solution. Blood and perfusate samples were collected during the perfusion. Additional blood samples were taken up to 2 h after the end of perfusion. The analysis was performed by liquid chromatography and post-column derivatization with N,N-diethyldithiocarbamate using microwave heating. Results The mean elimination half-life of oxaliplatin in the perfusate was 29.5 min (range 21.1-41.2 min) and in the peripheral circulation 24.7 min (range 21.7-27.7 min). The ratio of the areas under the time concentration curve in perfusate and blood was 12.8 +/- 2.9. Conclusion The systemic exposure of oxaliplatin measured after HIPEC using a selective analytical technique is considerably lower than previously reported results obtained by atomic absorption spectroscopy.
Place, publisher, year, edition, pages
2008. Vol. 64, no 9, 907-911 p.
intraperitoneal chemotherapy, hyperthermia, pharmacokinetics, oxaliplatin
Medical and Health Sciences Pharmaceutical Sciences
IdentifiersURN: urn:nbn:se:uu:diva-17405DOI: 10.1007/s00228-008-0511-9ISI: 000258882900013PubMedID: 18563401OAI: oai:DiVA.org:uu-17405DiVA: diva2:45176