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Borrelia infection and risk of non-Hodgkin lymphoma
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2008 (English)In: Blood, ISSN 0006-4971, Vol. 111, no 12, 5524-5529 p.Article in journal (Refereed) Published
Abstract [en]

Reports of the presence of Borrelia burgdorferiDNA in malignant lymphomas have raised the hypothesis that infection with B burgdorferi may be causally related to non-Hodgkin lymphoma (NHL) development. We conducted a Danish-Swedish case-control study including 3055 NHL patients and 3187 population controls. History of tick bite or Borrelia infection was ascertained through structured telephone interviews and through enzyme-linked immunosorbent assay serum analyses for antibodies against B burgdorferi in a subset of 1579 patients and 1358 controls. Statistical associations with risk of NHL, including histologic subtypes, were assessed by logistic regression. Overall risk of NHL was not associated with self-reported history of tick bite (odds ratio [OR] = 1.0, 95% confidence interval: 0.9-1.1), Borrelia infection (OR = 1.3 [0.96-1.8]) or the presence of anti-Borrelia antibodies (OR = 1.3 [0.9-2.0]). However, in analyses of NHL subtypes, self-reported history of B burgdorferi infection (OR = 2.5 [1.2-5.1]) and seropositivity for anti-Borrelia antibodies (OR = 3.6 [1.8-7.4]) were both associated with risk of mantle cell lymphoma. Notably, this specific association was also observed in persons who did not recall Borrelia infection yet tested positive for anti-Borrelia antibodies (OR = 4.2 [2.0-8.9]). Our observations suggest a previously unreported association between B burgdorferi infection and risk of mantle cell lymphoma.

Place, publisher, year, edition, pages
2008. Vol. 111, no 12, 5524-5529 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-17411DOI: 10.1182/blood-2007-08-109611ISI: 000256786500023PubMedID: 18424667OAI: oai:DiVA.org:uu-17411DiVA: diva2:45182
Available from: 2008-06-24 Created: 2008-06-24 Last updated: 2009-11-04Bibliographically approved

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