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Telomere length and correlation with histopathogenesis in B-cell leukemias/lymphomas
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. (Lymfomgruppen)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. (Lymfomgruppen)
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2007 (English)In: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 78, no 4, 283-289 p.Article in journal (Refereed) Published
Abstract [en]

Telomere length was recently reported to correlate with cellular origin of B-cell malignancies in relation to the germinal center (GC). In this report, we measured telomere length by quantitative-PCR in 223 B-cell lymphomas/leukemias and correlated results with immunoglobulin (Ig) mutation status and immunostainings for GC/non-GC subtypes of diffuse large B-cell lymphoma (DLBCL). Shortest telomeres were found in Ig-unmutated chronic lymphocytic leukemia (CLL) [median telomere to single copy gene value (T/S) 0.33], differing significantly to Ig-mutated CLL (0.63). Contrary to this, mantle cell lymphomas (MCLs) exhibited similar telomere lengths regardless of Ig mutation status (0.47). Telomere length differed significantly between GC-like (0.73) and non-GC-like DLBCLs (0.43), and follicular lymphomas (FLs) had shorter telomeres (0.53) than GC-DLBCL. Hairy cell leukemias, which display Ig gene intraclonal heterogeneity, had longer telomeres (0.62) than FLs and non-GC-DLBCL, but shorter than GC-DLBCL. We conclude that although DLBCL and CLL subsets can be clearly distinguished, telomere length reflects many parameters and may not simply correlate with GC-related origin.

Place, publisher, year, edition, pages
2007. Vol. 78, no 4, 283-289 p.
Keyword [en]
B-cell malignancy, Chronic lymphocytic leukemia, Diffuse large B-cell lymphoma, Germinal center origin, Mantle cell lymphomas, Telomere length
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-17463DOI: 10.1111/j.1600-0609.2007.00817.xISI: 000244718800002PubMedID: 17286609OAI: oai:DiVA.org:uu-17463DiVA: diva2:45234
Available from: 2008-06-24 Created: 2008-06-24 Last updated: 2017-12-08Bibliographically approved

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Berglund, MattiasThunberg, UlfLaurell, AnnaEnblad, Gunilla

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