uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Show others and affiliations
2011 (English)In: Nature, ISSN 0028-0836, Vol. 478, no 7367, 103-109 p.Article in journal, Letter (Refereed) Published
Abstract [en]

Blood pressure is a heritable trait(1) influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (>= 140 mm Hg systolic blood pressure or >= 90 mm Hg diastolic blood pressure)(2). Even small increments in blood pressure are associated with an increased risk of cardiovascular events(3). This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.

Place, publisher, year, edition, pages
2011. Vol. 478, no 7367, 103-109 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-160720DOI: 10.1038/nature10405ISI: 000295575400043OAI: oai:DiVA.org:uu-160720DiVA: diva2:453188
Available from: 2011-11-01 Created: 2011-10-31 Last updated: 2011-11-01Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Gyllensten, Ulf B.
By organisation
Department of Immunology, Genetics and Pathology
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 181 hits
ReferencesLink to record
Permanent link

Direct link