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Dynamic control of TGF-beta signaling and its links to the cytoskeleton
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
2008 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 582, no 14, 2051-2065 p.Article, review/survey (Refereed) Published
Abstract [en]

Transforming growth factor beta (TGF-beta) regulates cellular behavior in embryonic and adult tissues. TGF-beta binding to serine/threonine kinase receptors on the plasma membrane activates Smad molecules and additional signaling proteins that coordinately regulate gene expression or cytoplasmic processes such as cytoskeletal dynamics. In turn, the activity and duration of the Smad pathway seems to be regulated by cytoskeletal components, which facilitate the shuttling process that segregates Smad proteins in the cytoplasm and nucleus. We discuss mechanisms and models that aim at explaining the coordination between several components of the signaling network downstream of the TGF-beta signal.

Place, publisher, year, edition, pages
Elsevier B.V. , 2008. Vol. 582, no 14, 2051-2065 p.
Keyword [en]
Actin, BMP, microtubule, smad, signal transduction, TGF-beta, transportin
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-17557DOI: 10.1016/j.febslet.2008.03.027ISI: 000257387100015PubMedID: 18375206OAI: oai:DiVA.org:uu-17557DiVA: diva2:45328
Available from: 2008-07-10 Created: 2008-07-10 Last updated: 2017-12-08Bibliographically approved

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Moustakas, AristidisHeldin, Carl-Henrik

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