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Cetirizine in horses: Pharmacokinetics and pharmacodynamics following repeated oral administration
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry.
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2008 (English)In: The Veterinary Journal, ISSN 0007-1935, E-ISSN 1879-3606, Vol. 177, no 2, 242-249 p.Article in journal (Refereed) Published
Abstract [en]

The pharmacokinetics of the histamine HI-antagonist cetirizine and its effect on histamine-induced cutaneous wheal formation were studied in six healthy horses following repeated oral administration. After three consecutive administrations of cetirizine (0.2 mg/kg body weight, bw) every 12 h, the trough plasma concentration of cetirizine was 16 +/- 4 ng/mL (mean +/- SD) and the wheal formation was inhibited by 45 +/- 23%. After four additional administrations of cetirizine (0.4 mg/kg bw) every 12 h, the trough plasma concentration was 48 +/- 15 ng/mL and the wheal formation was inhibited by 68 +/- 11%. The terminal half-life was about 5.8 h. A pharmacokinetic/ pharmacodynamic link model showed that the maximal inhibition of wheal formation was about 95% and the EC50 about 18 ng/mL. It is concluded that cetirizine in doses of 0.2-0.4 mg/kg bw administered at 12 h intervals exhibits favourable pharmacokinetic and pharmacodynamic properties without causing visible side effects, and the drug may therefore be a useful antihistamine in equine medicine.

Place, publisher, year, edition, pages
2008. Vol. 177, no 2, 242-249 p.
Keyword [en]
horse, antihistamine, cetirizine, PK/PD link model
National Category
Veterinary Science
Identifiers
URN: urn:nbn:se:uu:diva-17639DOI: 10.1016/j.tvjl.2007.03.026ISI: 000257457600015PubMedID: 17581764OAI: oai:DiVA.org:uu-17639DiVA: diva2:45410
Available from: 2008-07-30 Created: 2008-07-30 Last updated: 2017-12-08Bibliographically approved

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