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Serum phospholipid and cholesteryl ester fatty acids and estimated desaturase activities are related to overweight and cardiovascular risk factors in adolescents
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Clinical Nutrition)
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2008 (English)In: International Journal of Obesity, ISSN 0307-0565, Vol. 32, no 8, 1297-1304 p.Article in journal (Refereed) Published
Abstract [en]

Aim/hypothesis: The objective of this study was to describe the relation of serum fatty acids and desaturase activity (DA) to overweight, insulin sensitivity and cardiovascular disease (CVD) risk factors in adolescents. Methods: The relations of % serum phospholipid (PL) and cholesteryl ester (CE) fatty acids and estimated DA with CVD risk factors were examined in 264 adolescents (average age 15 years). Fatty acids were determined by gas liquid chromotography. Surrogate measures of DA were expressed as ratios of serum fatty acids: Delta 9 DA 16: 0/16: 1, Delta 6 DA 20: 3, n6/18: 2, n6 (PL) or 18: 3, n6/18: 2, n6 (CE), and Delta 5 DA 20: 4, n6/20: 3, n6. Spearman partial correlations of fatty acids (%) and DA ratios with CVD risk factors were reported, adjusting for age, sex, race, Tanner stage, energy intake and physical activity. Results: Overweight adolescents compared to normal weight had more adverse levels of CVD risk factors, composition of PL and CE fatty acids in serum, and D6 DA and D5 DA ratios. Linoleic acid was inversely related to body mass index (BMI), waist circumference and triglycerides (P < ;= 0.01). Dihomo-gamma-linolenic acid was positively related to BMI, waist, insulin, and triglycerides, and inversely related to high-density lipoprotein-cholesterol levels (P < ;= 0.01). D6 DA was adversely associated with most of the risk factors (P < ;= 0.01), whereas triglycerides and fasting insulin were beneficially related to D5 DA (P < ;= 0.01). Conclusion: These findings support those observed in adults, that factors, such as type of dietary fat, physical activity, and obesity, may influence fatty acid metabolism and are important in the development of adverse CVD risk factors as early as adolescence.

Place, publisher, year, edition, pages
2008. Vol. 32, no 8, 1297-1304 p.
Keyword [en]
serum fatty acids, phospholipids, cholesteryl esters, cardiovascular risk factors, insulin sensitivity, adolescents
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-17690DOI: 10.1038/ijo.2008.89ISI: 000258359600013PubMedID: 18560369OAI: oai:DiVA.org:uu-17690DiVA: diva2:45461
Available from: 2008-08-15 Created: 2008-08-15Bibliographically approved

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Vessby, B
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