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The Imaging Continuum: Bench to Biomarkers to Diagnostics
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
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2007 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 50, no 9-10, 746-769 p.Article, review/survey (Refereed) Published
Abstract [en]

Innovation in basic and applied science has brought radiotracers to fruition as diagnostics. Non-invasive, longitudinal, and quantifiable molecular imaging is the key to diagnosing and monitoring numerous illnesses, with more to come from characterization of the clinical relevance of findings from genomics research. Radiotracers enable real-time in vivo studies of the effects of drug candidates on receptors, pathways, pharmacodynamics, and clinically relevant endpoints, thereby providing both early detection of pathophysiology to enable early intervention, and then monitoring of treatment responses to enable individualization of treatment regimens. We review developments which have translated imaging from bench to bedside, or biomarkers to diagnostics. Notable developments include (1) synthesis methods for rapid 11C labeling of biomolecules to high specific radioactivity; (2) ligand-binding assays for screening molecular imaging agents rather than drugs; (3) in vivo imaging of radiotracers in animals; (4) discovering the imaging advantages of 99mTc, 11C, and 18F; (5) co-registration and automated quantitative assessment of high spatial resolution CT and MR images with molecular images from PET for longitudinal studies of treatment effect.

Place, publisher, year, edition, pages
2007. Vol. 50, no 9-10, 746-769 p.
Keyword [en]
positron emission tomography, biomarkers, radiodiagnostics, radiopharmaceuticals, radiotracers
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-17755DOI: 10.1002/jlcr.1444ISI: 000250889100003OAI: oai:DiVA.org:uu-17755DiVA: diva2:45526
Available from: 2008-08-22 Created: 2008-08-22 Last updated: 2017-12-08Bibliographically approved

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Långström, BengtAntoni, Gunnar

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