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Effects of Amphiphilic Copolymers Bearing Short Blocks of Lipid-Mimetic Units on the Membrane Properties and Morphology of DSPC Liposomes
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry, Physical Chemistry.
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2008 (English)In: Journal of Dispersion Science and Technology, ISSN 0193-2691, E-ISSN 1532-2351, Vol. 29, no 8, 1106-1113 p.Article in journal (Refereed) Published
Abstract [en]

Amphiphilic, nonionic diblock copolymers based on poly(ethylene glycol) (PEG 2000-5000), comprising short blocks of lipid-mimetic units, where tested for their ability to afford steric stabilization of distearoylphosphathydilcholine:cholesterol liposomes. The copolymers bear 1-4 lipid-mimetic anchors per copolymer chain. Effects on liposomes size depend on copolymer type and content. Cryo-TEM reveals well-sepd., intact, predominantly spherical liposomes at copolymer contents up to 5 mol%. A "flat" liposomes fraction occurs upon incorporation of above 7.5 mol% of copolymers bearing 2 or 4 lipid anchors. 5,6-carboxyfluorescein assay indicates lower leakage of stabilized vs. plain liposomes up to concn. 7.5 mol%. Leakage from liposomes with higher copolymer concn. is insignificantly greater.

Place, publisher, year, edition, pages
2008. Vol. 29, no 8, 1106-1113 p.
Keyword [en]
block copolymers, DSPC liposomes, PEG-lipids, steric stabilization
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-17768DOI: 10.1080/01932690701817750ISI: 000258621700013OAI: oai:DiVA.org:uu-17768DiVA: diva2:45539
Available from: 2008-08-25 Created: 2008-08-25 Last updated: 2017-12-08Bibliographically approved

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Karlsson, GöranAlmgren, Mats

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