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Prevalence of psychiatric disorders in infertile women and men undergoing in vitro fertilization treatment
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
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2008 (English)In: Human Reproduction, ISSN 0268-1161, E-ISSN 1460-2350, Vol. 23, no 9, 2056-2063 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: This study was undertaken to determine the prevalence of psychiatric disorders in infertile women and men undergoing in vitro fertilization (IVF) treatment. METHODS: Participants were 1090 consecutive women and men, 545 couples, attending a fertility clinic in Sweden during a two-year period. The Primary Care Evaluation of Mental Disorders (PRIME-MD), based on the Diagnostic and Statistical Manual of Mental Disorders, 4th edn (DSM-IV), was used as the diagnostic tool for evaluating mood and anxiety disorders. RESULTS: Overall, 862 (79.1%) subjects filled in the PRIME-MD patient questionnaire. Any psychiatric diagnosis was present in 30.8% of females and in 10.2% of males in the study sample. Any mood disorder was present in 26.2% of females and 9.2% of males. Major depression was the most common mood disorder, prevalent in 10.9% of females and 5.1% of males. Any anxiety disorder was encountered in 14.8% of females and 4.9% males. Only 21% of the subjects with a psychiatric disorder according to DSM-IV received some form of treatment. CONCLUSIONS: Mood disorders are common in both women and men undergoing IVF treatment. The majority of subjects with a psychiatric disorder were undiagnosed and untreated.

Place, publisher, year, edition, pages
2008. Vol. 23, no 9, 2056-2063 p.
Keyword [en]
Depression, anxiety, women, men, in vitro fertilization
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-17795DOI: 10.1093/humrep/den154ISI: 000259144600014PubMedID: 18583334OAI: oai:DiVA.org:uu-17795DiVA: diva2:45566
Available from: 2008-09-01 Created: 2008-09-01 Last updated: 2017-12-08Bibliographically approved
In thesis
1. Mood Disorders, Personality and Grief in Women and Men undergoing in vitro Fertilization Treatment
Open this publication in new window or tab >>Mood Disorders, Personality and Grief in Women and Men undergoing in vitro Fertilization Treatment
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Psychological problems are common in infertile women undergoing in vitro fertilization (IVF) treatment.  The aim of this thesis was to determine the prevalence of psychiatric disorders, such as mood and anxiety disorders, and related risk factors and personality traits in women and men undergoing IVF.

Participants were 1090 consecutive women and men, 545 couples, attending a fertility clinic in Sweden during a two-year period. The Primary Care Evaluation of Mental Disorders (PRIME-MD), based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), was used for evaluating mood and anxiety disorders. The participation rate was 862 (79 %) subjects.

Any psychiatric disorder was present in 31 % of females and in 10 % of males. Major depression was prevalent in 11 % of females and 5 % of males. Only 21 % of the subjects with a psychiatric disorder had some form of treatment. A negative pregnancy test and obesity (BMI ≥ 30) were risk factors for mood disorders in women and the only risk factor for depression in men was unexplained infertility. Anxiety disorders were less common than in the general population and no IVF-related risk factors were identified. The Swedish universities Scales of Personality (SSP), a self-rating questionnaire, was used for evaluation of personality traits. High scores of personality traits related to neuroticism were associated with mood and/or anxiety disorders among both women and men.

Another objective was to explore the experience of childlessness three years after unsuccessful IVF by a qualitative-approach, assessing data by interviews. Failure after IVF was experienced by women in terms of grief, whereas men took upon themselves a supportive role not expressing grief. A need for professional support and counselling in how to handle grief was described. An unstructured end after IVF treatment left unanswered questions. Three years after the end of treatment, men and women were still processing and had not adapted to childlessness, indicating the grieving process was unresolved.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2009. 67 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 489
Keyword
infertility, in vitro fertilization, depression, anxiety, personality, neuroticism, grief, unsuccessful IVF
National Category
Obstetrics, Gynecology and Reproductive Medicine
Research subject
Obstetrics and Gynaecology
Identifiers
urn:nbn:se:uu:diva-109464 (URN)978-91-554-7630-4 (ISBN)
Public defence
2009-11-27, IX Universitetshuset, Övre Slottsgatan 2, Uppsala, 13:15 (Swedish)
Opponent
Supervisors
Available from: 2009-11-06 Created: 2009-10-15 Last updated: 2011-01-12Bibliographically approved

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Volgsten, HelenaSkoog Svanberg, AgnetaEkselius, LisaLundkvist, ÖrjanSundström Poromaa, Inger

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