uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Maternal enterovirus infection during pregnancy as a risk factor in Offspring Diagnosed with Type 1 Diabetes between 15 and 30 years of age
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Barnendokrinologisk forskning/Gustafsson)
Show others and affiliations
2008 (English)In: Experimental Diabetes Research, ISSN 1687-5214, 271958- p.Article in journal (Refereed) Published
Abstract [en]

Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring's risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulin M (IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for enterovirus RNA (n.s.). Boys of enterovirus IgM-positive mothers had approximately 5 times greater risk of developing diabetes (OR 4.63; 95% CI 1.22-17.6), as compared to boys of IgM-negative mothers (P < .025). These results suggest that gestational enterovirus infections may be related to the risk of offspring developing type 1 diabetes in adolescence and young adulthood.

Place, publisher, year, edition, pages
2008. 271958- p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-17798DOI: 10.1155/2008/271958ISI: 000267260800001OAI: oai:DiVA.org:uu-17798DiVA: diva2:45569
Available from: 2008-09-01 Created: 2008-09-01 Last updated: 2010-07-23Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Department of Women's and Children's Health
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 142 hits
ReferencesLink to record
Permanent link

Direct link