Biodegradable Ionomers for the Loading and Release of Proteins : Formation, Characterization, Mechanism, and Consequence of Water Uptake
2008 (English)In: / [ed] Mahapatro A, Kulshrestha AS, 2008, Vol. 977, 250-266 p.Conference paper (Refereed)
The increased understanding of proteins and the human genome point towards a future in which selective proteins may replace synthetic drugs in the general cure of disease. In this scenario the ability of controlled and gentle release of proteins provide the key for successful treatment. To address the ability of full protein delivery we have developed a series of telechelic biodegradable ionomers based on poly (trimethylene carbonate) carrying zwitterionic, anionic or cationic functional groups. The introduction of polar end-groups provides a material with unique properties that directs the introduced functionality within the material bulk but also to the material surface if water is introduced. Bulk aggregation provide a low elastic modulus material and the ability to surface enrich provide the on-set of water swelling. The latter finally results in a co-continuous water-ionomer structure that engulfs and stores proteins simply by soaking the material in an aqueous protein solution. Following protein loading the material can be dried and re-immersed in water so that release occurs. Our results, including both the careful synthesis and the ability to load and release proteins, provides new possibilities for full protein delivery.
In this chapter the increased understanding of the water swelling properties and the subsequent formation of bulk water domains in biodegradable poly (trimethylene carbonate) (PTMC) ionomers is presented. The recent discovery that A functional PTMC may be functionalized with polar co-phosphoryl choline (PC) end groups and that the resulting telechelic zwitter ionomer forms an interesting low elastic modulus material has encouraged and directed the use of biodegradable ionomers in new areas of biomaterial research (I). Present findings now suggest that the scope of the synthesis may be broadened to provide telechelic ionomers with additional functionalities (2) and also that the water absorbing properties of such ionomers indicate their potential to serve as novel carriers for the loading and release of proteins (3).
Place, publisher, year, edition, pages
2008. Vol. 977, 250-266 p.
, ACS Symposium Series, ISSN 0097-6156 ; 977
Physical Sciences Engineering and Technology
Research subject Engineering Science with specialization in Nanotechnology and Functional Materials
IdentifiersURN: urn:nbn:se:uu:diva-17806ISI: 000290249500017ISBN: 978-0-8412-3966-1OAI: oai:DiVA.org:uu-17806DiVA: diva2:45577
International Symposium on Polymers for Biomedical Applications/232nd National Meeting of the American-Chemical-Society (ACS) San Francisco, CA, SEP 10-14, 2006