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Recombinant hirudin in clinical practice: focus on lepirudin.
(Department of Transfusion Medicine, Greifswald University, Germany)
2001 (English)In: Circulation, ISSN 0009-7322, E-ISSN 1524-4539, Vol. 103, no 10, 1479-84 p.Article in journal (Refereed) Published
Abstract [en]

Clinical applications for recombinant hirudins have been investigated for the past 10 years. The first indication for which a hirudin-lepirudin-has been approved is treatment of heparin-induced thrombocytopenia (HIT). Also, the recently completed trials for use of lepirudin in unstable angina indicate a potentially new indication. This review describes pharmacology and clinical applications of lepirudin with an emphasis on HIT and unstable angina. An overview of usage of lepirudin in acute coronary syndromes is given, as well as a summary of rare indications for lepirudin, such as extracorporeal circulation, for which comprehensive data are lacking.

Place, publisher, year, edition, pages
2001. Vol. 103, no 10, 1479-84 p.
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Clinical Medicine
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URN: urn:nbn:se:uu:diva-161383PubMedID: 11245656OAI: oai:DiVA.org:uu-161383DiVA: diva2:455971
Available from: 2011-11-11 Created: 2011-11-11 Last updated: 2017-12-08

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