uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Heparin-induced thrombocytopenia: recommendations for optimal use of recombinant hirudin.
Department of Transfusion Medicine, Greifswald University, Germany.
2000 (English)In: BioDrugs, ISSN 1173-8804, Vol. 14, no 2, 109-25 p.Article in journal (Refereed) Published
Abstract [en]

Recombinant hirudins have a definite role in the treatment of patients with heparin-induced thrombocytopenia (HIT). The most important adverse effects are haemorrhages and the induction of antihirudin antibodies. Major haemorrhages were not significantly increased in patients with HIT compared with a historical control group, but prospective data comparing hirudin and heparinoids such as danaparoid are lacking. The definition of the optimal method for monitoring and the availability of an antidote for hirudin would probably increase safety with this drug. To date, haemofiltration using high-flux filter systems is the only way to remove an overdosage of hirudin from the circulation. In patients with renal impairment requiring hirudin treatment, it therefore seems safer to start with a low dose that is subsequently adjusted according to the activated partial prothromboplastin time or ecarin clotting time. Even in special circumstances, such as cardiopulmonary bypass or dialysis, hirudins can be applied successfully if care is taken to monitor their effects meticulously. There are many other indications in which hirudins have shown feasibility (e.g. acute coronary syndromes) but available data preclude definite conclusions.

Place, publisher, year, edition, pages
2000. Vol. 14, no 2, 109-25 p.
National Category
Clinical Medicine
URN: urn:nbn:se:uu:diva-161354PubMedID: 18034563OAI: oai:DiVA.org:uu-161354DiVA: diva2:456042
Available from: 2011-11-11 Created: 2011-11-11 Last updated: 2011-11-30

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Lubenow, Norbert
In the same journal
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 132 hits
ReferencesLink to record
Permanent link

Direct link