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Population based study of prognostic factors and treatment in adult Burkitt lymphoma: a Swedish Lymphoma Registry study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
2011 (English)In: Leukemia and Lymphoma, ISSN 1042-8194, E-ISSN 1029-2403, Vol. 52, no 11, 2090-2096 p.Article in journal (Refereed) Published
Abstract [en]

Burkitt lymphoma (BL) is a rare neoplasm constituting 1-2% of adult lymphomas. Our aims in this study were to establish prognostic factors for overall survival in adult BL and evaluate the efficacy of different chemotherapy regimens in a population based setting. The study population was collected from the Swedish Lymphoma Registry 2000-2010. During this period, 156 adult patients with BL were identified. In multivariate analysis, age and performance status (PS) were significant adverse prognostic factors for overall survival. A modified prognostic index, based on: age >40 years, PS >1, and lactate dehydrogenase > upper limit of normal (ULN) was proposed. Patients with a score of 0-1, 2, and 3 were found to have a 2-year survival of 91.2%, 58.4%, and 27.5%, respectively. High-intensity regimens were associated with more favorable overall survival. Rituximab addition was not significantly associated with improvement in survival. A modified prognostic index may be valuable for adult BL, as proposed.

Place, publisher, year, edition, pages
2011. Vol. 52, no 11, 2090-2096 p.
Keyword [en]
Burkitt lymphoma, population, adult, chemotherapy, rituximab
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-161438DOI: 10.3109/10428194.2011.593274ISI: 000296163000012OAI: oai:DiVA.org:uu-161438DiVA: diva2:456840
Available from: 2011-11-16 Created: 2011-11-14 Last updated: 2017-12-08Bibliographically approved

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