uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action.
2002 (English)In: Diabetes, ISSN 0012-1797, E-ISSN 1939-327X, Vol. 51 Suppl 1, S33-6 p.Article in journal (Refereed) Published
Abstract [en]

Several reports indicate that hypoglycemic sulfonylureas augment Ca(2+)-dependent insulin secretion via mechanisms other than inhibition of the ATP-sensitive K(+) channel. The effect involves a 65-kd protein in the granule membrane and culminates in intragranular acidification. Lowering of granule pH is necessary for the insulin granule to gain release competence. Proton pumping into the granule is driven by a v-type H(+)-ATPase, but requires simultaneous Cl(-) uptake into the granule via metabolically regulated ClC-3 Cl(-) channels to maintain electroneutrality. Here we discuss the possibility that modulation of granule ClC-3 channels represents the mechanism whereby sulfonylureas directly potentiate the beta-cell exocytotic machinery.

Place, publisher, year, edition, pages
2002. Vol. 51 Suppl 1, S33-6 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-161873PubMedID: 11815455OAI: oai:DiVA.org:uu-161873DiVA: diva2:457782
Available from: 2011-11-19 Created: 2011-11-19 Last updated: 2011-11-19

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Barg, Sebastian
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 277 hits
ReferencesLink to record
Permanent link

Direct link