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A lactoferrin-derived peptide (PXL01) for the reduction of adhesion formation in flexor tendon surgery: an experimental study in rabbits
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Hand Surgery.
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2011 (English)In: Journal of Hand Surgery (European Volume), ISSN 1753-1934, Vol. 36E, no 8, 656-662 p.Article in journal (Refereed) Published
Abstract [en]

Injuries to flexor tendons can lead to loss of finger function after healing due to adhesion formation. The aim of this study was to assess the efficacy and safety of the new peptide, PXL01, in the prevention of peritendinous adhesions. The effect of a single intraoperative administration of PXL01 in sodium hyaluronate on mobility of the affected digit after surgery was assessed in a rabbit model by measuring total active motion, metatarsophalangeal-claw distance and resistance to bending the digits. Load-to-failure testing was done in the same specimens to assess tendon healing. The results demonstrated that a single application of PXL01 in sodium hyaluronate significantly improved mobility of the treated digits compared with the digits in which the same surgery was carried out but no treatment was provided. No negative effects on tendon healing were observed in connection with the treatment.

Place, publisher, year, edition, pages
2011. Vol. 36E, no 8, 656-662 p.
Keyword [en]
Flexor tendon, lactoferrin, sodium hyaluronate, adhesions, rabbit
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URN: urn:nbn:se:uu:diva-161565DOI: 10.1177/1753193411410823ISI: 000296059900004OAI: oai:DiVA.org:uu-161565DiVA: diva2:457846
Available from: 2011-11-20 Created: 2011-11-15 Last updated: 2011-11-20Bibliographically approved

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Wiig, M.
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