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Does Growth Hormone Treatment Influence Pubertal Development in Short Children?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
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2011 (English)In: Hormone Research in Paediatrics, ISSN 1663-2818, Vol. 76, no 4, 262-272 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To study the influence of growth hormone (GH) treatment on the initiation and progression of puberty in short children.

Methods: This prospective, randomized, controlled study included 124 short children (33 girls) who received GH treatment (Genotropin (R); Pfizer Inc.) from a mean age of 11 years until near adult height [intent-to-treat (ITT) population]. Children were randomized into three groups: controls (n = 33), GH 33 mu g/kg/day (n = 34) or GH 67 mu g/kg/day (n = 57). Prepubertal children at study start constituted the per-protocol (PP) population (n = 101). Auxological measurements were made and puberty was staged every 3 months. Serum sex-steroid concentrations were assessed every 6 months.

Results: No significant differences were found between the groups, of both PP and ITT populations, in time elapsed from start of treatment until either onset of puberty, age at start of puberty or age at final pubertal maturation in either sex. In the ITT population, pubertal duration was significantly longer in GH-treated girls, and maximum mean testicular volume was significantly greater in GH-treated boys than controls, but there were no differences in testosterone levels between the groups.

Conclusion: GH treatment did not influence age at onset of puberty and did not accelerate pubertal development. In boys, GH treatment appeared to increase testicular volume.

Place, publisher, year, edition, pages
2011. Vol. 76, no 4, 262-272 p.
Keyword [en]
Pubertal onset, Testosterone, Testes, Growth hormone treatment
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-161959DOI: 10.1159/000329743ISI: 000296392700007OAI: oai:DiVA.org:uu-161959DiVA: diva2:457933
Available from: 2011-11-21 Created: 2011-11-21 Last updated: 2011-11-21Bibliographically approved

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Tuvemo, Torsten

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