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Novel Polymeric Nanoparticles Assembled by Metal Ion Addition
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic .
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic.
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry, Physical Chemistry.
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2011 (English)In: Macromolecular Chemistry and Physics, ISSN 1022-1352, E-ISSN 1521-3935, Vol. 212, no 21, 2339-2348 p.Article in journal (Refereed) Published
Abstract [en]

Potentially biodegradable graft polymer core-shell nanoparticles assembling by addition of metal ions intended to be used for radionuclide and drug delivery purposes are described. With Cu2+ ions, the self-assembly is slow (within minutes) with low efficiency. With Fe3+ ions the nanoparticles are formed immediately and are of convenient size for passive tumor accumulation by the enhanced permeation and retention effect. Full in vitro degradation of these particles is achieved with deferoxamine as a model of in vivo transchelation capacity.

Place, publisher, year, edition, pages
2011. Vol. 212, no 21, 2339-2348 p.
Keyword [en]
drug delivery systems, hydroxamic acid, nanoparticles, self-assembly
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-161975DOI: 10.1002/macp.201100431ISI: 000297411600006OAI: oai:DiVA.org:uu-161975DiVA: diva2:458009
Available from: 2011-11-21 Created: 2011-11-21 Last updated: 2017-12-08Bibliographically approved

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Karlsson, Göran

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