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Inflammation-associated graft loss in renal transplant recipients
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2011 (English)In: Nephrology, Dialysis and Transplantation, ISSN 0931-0509, E-ISSN 1460-2385, Vol. 26, no 11, 3756-3761 p.Article in journal (Refereed) Published
Abstract [en]

Background. Although short-term graft survival has improved substantially in renal transplant recipients, long-term graft survival has not improved over the last decades. The lack of knowledge of specific causes and risk factors has hampered improvements in long-term allograft survival. There is an uncertainty if inflammation is associated with late graft loss.

Methods. We examined, in a large prospective trial, the inflammation markers high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) and their association with chronic graft dysfunction. We collected data from the Assessment of Lescol in Renal Transplant trial, which recruited 2102 maintenance renal transplant recipients.

Results. Baseline values were hsCRP 3.8 +/- 6.7 mg/L and IL-6 2.9 +/- 1.9 pg/mL. Adjusted for traditional risk factors, hsCRP and IL-6 were independently associated with death-censored graft loss, the composite end points graft loss or death and doubling of serum creatinine, graft loss or death.

Conclusion. The inflammation markers hsCRP and IL-6 are associated with long-term graft outcomes in renal transplant recipients.

Place, publisher, year, edition, pages
2011. Vol. 26, no 11, 3756-3761 p.
Keyword [en]
ALERT, high-sensitivity CRP, inflammation, interleukin-6, renal allograft survival
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-161924DOI: 10.1093/ndt/gfr163ISI: 000296350400053OAI: oai:DiVA.org:uu-161924DiVA: diva2:458548
Available from: 2011-11-23 Created: 2011-11-21 Last updated: 2017-12-08Bibliographically approved

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Fellström, Bengt

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