The A118G Single Nucleotide Polymorphism of Human μ–Opioid Receptor Gene and Use of Labor Analgesia
2012 (English)In: Reproductive Sciences, ISSN 1933-7191, Vol. 19, no 9, 962-967 p.Article in journal (Refereed) Published
The human µ-opioid receptor (MOR) is the major site of action of endogenous opioids and most of the clinically used opioid analgesics. The single-nucleotide polymorphism (SNP), A118G of the MOR 1 gene (OPRM1), has been associated with altered pain perception. The aim of this study was to investigate whether this polymorphism of OPRM1 is associated with a number of pain-related behaviors during labor. In this observational retrospective population-based study, pregnant women (n = 814) were recruited at gestational week 18. A plasma sample was collected from each participant and an SNP genotyping assay was performed. No differences in sociodemographic variables or labor pain-related outcomes, such as stage of cervical dilation on arrival at the delivery unit or use of any type of second-line analgesia during spontaneous labor, were found between noncarriers and G-allele carriers of OPRM1. We conclude that there is no association between the A118G polymorphism of OPRM1 regarding pain-related behavior during labor.
Place, publisher, year, edition, pages
2012. Vol. 19, no 9, 962-967 p.
analgesia, labor pain, OPRM1, single nucleotide polymorphism
Obstetrics, Gynecology and Reproductive Medicine
Research subject Obstetrics and Gynaecology
IdentifiersURN: urn:nbn:se:uu:diva-162543DOI: 10.1177/1933719112438970ISI: 000307540200007OAI: oai:DiVA.org:uu-162543DiVA: diva2:460698
ProjectsGenetics and Labor Pain Behavior