uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Degree of compression as a potential process control tool of tablet tensile strength
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2011 (English)In: Pharmaceutical development and technology (Print), ISSN 1083-7450, E-ISSN 1097-9867, Vol. 16, no 6, 599-608 p.Article in journal (Refereed) Published
Abstract [en]

The current view on the development and manufacturing of pharmaceutical preparations points towards improved control tools that can be implemented in pharmaceutical manufacturing as a means to better control end product properties. The objective of this paper was to investigate the relationship between tablet tensile strength and the degree of bed compression in order to evaluate the suitability of assessing the straining of the powder bed during tableting as a process control tool of tablet tensile strength. Microcrystalline cellulose was used as powder raw material and subjected to wet granulation by different procedures to create agglomerates of different physical and compression properties. The produced agglomerates thus showed a large variation in compressibility and compactibility. However, in terms of the relationship between the degree of compression and the tablet tensile strength, all agglomerates gathered reasonably around a single general relationship. The degree of compression hence appears to be a potential valuable process control tool of the tablet tensile strength that may enable the use of an adaptive tableting process with improved product quality consistency.

Place, publisher, year, edition, pages
2011. Vol. 16, no 6, 599-608 p.
Keyword [en]
Compaction, compression, engineering strain, granular materials, powder technology, tableting
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-162463DOI: 10.3109/10837450.2010.502177ISI: 000296652200005OAI: oai:DiVA.org:uu-162463DiVA: diva2:460706
Available from: 2011-12-01 Created: 2011-11-30 Last updated: 2017-12-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Nordström, JosefinaAlderborn, Göran

Search in DiVA

By author/editor
Nordström, JosefinaAlderborn, Göran
By organisation
Department of Pharmacy
In the same journal
Pharmaceutical development and technology (Print)
Pharmaceutical Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 337 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf